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binding ligands of the EGF family and 

activating several signaling cascades to 

convert extracellular cues into appropriate 

cellular responses. It activates at least 4 major 

downstream signaling cascades including the 

RAS-RAF-MEK-ERK, PI3 kinase-AKT, 

PLCgamma-PKC and STATs modules. Defects 

in EGFR are associated with lung cancer (LNCR).

Immunogen: A synthetic peptide from the 

internal region of EGFR which includes the 

mutation of L858Q, human origin. 

Tested applications: ELISA, WB, IF, IHC

Recommended dilutions:

ELISA:  1:1000-1:5000

WB:     1:500-1:1000

IHC:     1:50-1:100

Concentration: 1 mg/ml

Host: Mouse

Clonality: Monoclonal

Purity: Purified from ascites

Format: Liquid

Storage buffer: 

Preservative: no

Constituents: PBS (without Mg2+ and Ca2+), 

pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: Recognizes EGFR (L858Q), 

but not wild type EGFR protein from vertebrates.

Storage Conditions: Store at -20°C. Avoid 

freeze / thaw cycles.